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Pravastatin Sodium Salt

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Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.1 Pravastatin is a HMG-CoA reductase inhibitor that is a ring hydroxylated metabolite of mevastatin.2 It is a competitive inhibitor of HMG-CoA reductase with a Ki value of 2.3 nM for the active, open ring form of the molecule.2 Pravastatin, marketed as Pravachol™ or Lipostat™, is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. In a study using dogs, five weeks of treatment with a dose 20 mg/kg per day reduced total plasma cholesterol levels by 29%.

Product Details

Category API's & Drug Standards
Diabetes Research
Price POA
CAS Number 81131-70-6
Formula C23H35O7Na · xH2O
Molecular Weight 446.51(anhydrousbasis)
Purity 98.0%
Appearance crystalline white powder
Availability In Stock
Storage Conditions +4°C

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